High Expression Levels of Total IGF-1R and Sensitivity of NSCLC Cells In Vitro to an Anti-IGF-1R Antibody (R1507)

BACKGROUND: The IGF receptor type 1 (IGF-1R) pathway is frequently deregulated in human tumors and has become a target of interest for anti-cancer therapy. METHODOLOGY/PRINCIPAL FINDINGS: We used a panel of 22 non-small cell lung cancer (NSCLC) cell lines to investigate predictive biomarkers of resp...

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Detalhes bibliográficos
Main Authors: Gong, Yixuan, Yao, Evelyn, Shen, Ronglai, Goel, Aviva, Arcila, Maria, Teruya-Feldstein, Julie, Zakowski, Maureen F., Frankel, Stanley, Peifer, Martin, Thomas, Roman K., Ladanyi, Marc, Pao, William
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752171/
https://ncbi.nlm.nih.gov/pubmed/19806209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007273
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