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An intact connexin N-terminus is required for function but not gap junction formation

The cytoplasmic N-termini of connexins have been implicated in protein trafficking, oligomerization and channel gating. To elucidate the role of the N-terminus in connexin37 (CX37), we studied mutant constructs containing partial deletions of its 23 N-terminal amino acids and a construct with a comp...

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Detalhes bibliográficos
Main Authors: Kyle, John W., Minogue, Peter J., Thomas, Bettina C., Lopez Domowicz, Denise A., Berthoud, Viviana M., Hanck, Dorothy A., Beyer, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752142/
https://ncbi.nlm.nih.gov/pubmed/18664489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.032482
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