Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase

Analogues of the compound 2,5-di-tert-butylhydroquinone (BHQ) are capable of inhibiting the enzyme sarco/endoplasmic reticulum ATPase (SERCA) in the low micromolar and submicromolar concentration ranges. Not only are SERCA inhibitors valuable research tools, but they also have potential medicinal va...

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Main Authors: Paula, Stefan, Abell, Josh, Deye, Joel, Elam, Christopher, Lape, Michael, Purnell, Justin, Ratliff, Robert, Sebastian, Kelly, Zultowsky, Jodie, Kempton, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752035/
https://ncbi.nlm.nih.gov/pubmed/19699645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.07.075
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