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Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P 4503A4
It has been suggested that cytochrome P450 3A4 (CYP3A4) and MDR1 P-glycoprotein (P-gp) act synergistically to limit the bioavailability of orally administered agents. In order to determine the relative role of these proteins, it is essential to identify a selective inhibitor for either P-gp or CYP3A...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2751348/ https://ncbi.nlm.nih.gov/pubmed/11741214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps010418 |
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