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Molecular modeling of G-protein coupled receptor kinase 2: Docking and biochemical evaluation of inhibitors
G-protein coupled receptor kinase 2 (GRK2) regulates the activity of many receptors. Because potent inhibitors of GRK2 are thus far limited to polyanionic compounds like heparin, we searched for new inhibitors with the aid of a molecular model of GRK2. We used the available crystal structure of cAMP...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer-Verlag
2000
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2750997/ https://ncbi.nlm.nih.gov/pubmed/11741218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps020102 |
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