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Endosomal Targeting of MEK2 Requires RAF, MEK Kinase Activity and Clathrin-Dependent Endocytosis

To study spatiotemporal regulation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK1/2) signaling cascade in living cells, a HeLa cell line in which MAPK kinase of ERK kinase (MEK) 2 (MAPK kinase) was knocked down by RNA interference and replaced with the gre...

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Hlavní autoři: Galperin, Emilia, Sorkin, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750913/
https://ncbi.nlm.nih.gov/pubmed/18657070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2008.00788.x
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