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Shoc2 Is Targeted to Late Endosomes and Required for Erk1/2 Activation in EGF-Stimulated Cells

Shoc2 is the putative scaffold protein that interacts with RAS and RAF, and positively regulates signaling to extracellular signal-regulated protein kinases 1 and 2 (ERK1/2). To elucidate the mechanism by which Shoc2 regulates ERK1/2 activation by the epidermal growth factor (EGF) receptor (EGFR), w...

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Detalhes bibliográficos
Main Authors: Galperin, Emilia, Abdelmoti, Lina, Sorkin, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351432/
https://ncbi.nlm.nih.gov/pubmed/22606262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036469
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