Crystal structures of β-neurexin 1 and β-neurexin 2 ectodomains and dynamics of splice insertion sequence 4

Presynaptic neurexins (NRXs) bind to postsynaptic neuroligins (NLs) to form Ca(2+)-dependent protein complexes that bridge neural synapses. NRXs bind NLs through their membrane-proximal LNS domain, which contains a single site of alternative splicing (splice site 4) that gives rise to two isoforms:...

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Détails bibliographiques
Auteurs principaux: Koehnke, Jesko, Jin, Xiangshu, Trbovic, Nikola, Katsamba, Phinikoula S., Brasch, Julia, Ahlsen, Goran, Scheiffele, Peter, Honig, Barry, Palmer, Arthur, Shapiro, Lawrence
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750865/
https://ncbi.nlm.nih.gov/pubmed/18334216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.12.024
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