COMMD1 Promotes pVHL and O(2)-Independent Proteolysis of HIF-1α via HSP90/70

BACKGROUND: The Copper Metabolism MURR1 Domain containing 1 protein COMMD1 has been associated with copper homeostasis, NF-κB signaling, and sodium transport. Recently, we identified COMMD1 as a novel protein in HIF-1 signaling. Mouse embryos deficient for Commd1 have increased expression of hypoxia...

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Detalhes bibliográficos
Main Authors: van de Sluis, Bart, Groot, Arjan J., Vermeulen, Jeroen, van der Wall, Elsken, van Diest, Paul J., Wijmenga, Cisca, Klomp, Leo W., Vooijs, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750754/
https://ncbi.nlm.nih.gov/pubmed/19802386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007332
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