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In vitro and in vivo evaluations of biodegradable implants for hormone replacement therapy: Effect of system design and PK-PD relationship
This investigation evaluated the feasibility of using subdermally implantable devices fabricated by nonconventional 3-dimensional printing technology for controlled delivery of ethinyl estradiol (EE(2)). In vitro release kinetics of EE(2) and in vivo pharmacokinetics pharmacodynamics in ovariectomiz...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer-Verlag
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2750581/ https://ncbi.nlm.nih.gov/pubmed/14727875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/pt020316 |
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