Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

OBJECTIVE: Oxyntomodulin (OXM) is a glucagon-like peptide 1 (GLP-1) receptor (GLP1R)/glucagon receptor (GCGR) dual agonist peptide that reduces body weight in obese subjects through increased energy expenditure and decreased energy intake. The metabolic effects of OXM have been attributed primarily...

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Main Authors: Pocai, Alessandro, Carrington, Paul E., Adams, Jennifer R., Wright, Michael, Eiermann, George, Zhu, Lan, Du, Xiaobing, Petrov, Aleksandr, Lassman, Michael E., Jiang, Guoqiang, Liu, Franklin, Miller, Corey, Tota, Laurie M., Zhou, Gaochao, Zhang, Xiaoping, Sountis, Michael M., Santoprete, Alessia, Capito', Elena, Chicchi, Gary G., Thornberry, Nancy, Bianchi, Elisabetta, Pessi, Antonello, Marsh, Donald J., SinhaRoy, Ranabir
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2009
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750209/
https://ncbi.nlm.nih.gov/pubmed/19602537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0278
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