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Thymus-specific deletion of insulin induces autoimmune diabetes
Insulin expression in the thymus has been implicated in regulating the negative selection of autoreactive T cells and in mediating the central immune tolerance towards pancreatic β-cells. To further explore the function of this ectopic insulin expression, we knocked out the mouse Ins2 gene specifica...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2750011/ https://ncbi.nlm.nih.gov/pubmed/19680229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.212 |
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