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Single copy insertion of transgenes in C. elegans

Currently transgenes in C. elegans are generated by injecting DNA into the germline. The DNA assembles into a semi-stable extrachromosomal array composed of many copies of injected DNA. These transgenes are typically overexpressed in somatic cells and silenced in the germline. We have developed a me...

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Bibliografske podrobnosti
Main Authors: Frøkjær-Jensen, Christian, Davis, M. Wayne, Hopkins, Christopher E., Newman, Blake, Thummel, Jason M., Olesen, Søren-Peter, Grunnet, Morten, Jorgensen, Erik M.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749959/
https://ncbi.nlm.nih.gov/pubmed/18953339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.248
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