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Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters

BACKGROUND: Natural product structures have high chemical diversity and are attractive as lead structures for discovery of new drugs. One of the disease areas where natural products are most frequently used as therapeutics is oncology. METHOD AND FINDINGS: A library of natural products (NCI Natural...

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Bibliografiske detaljer
Main Authors: Fayad, Walid, Fryknäs, Mårten, Brnjic, Slavica, Olofsson, Maria Hägg, Larsson, Rolf, Linder, Stig
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749935/
https://ncbi.nlm.nih.gov/pubmed/19798419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007238
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