Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 2

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited, neurodegenerative disease caused by an expansion of polyglutamine tracts in the cytosolic protein ataxin-2 (Atx2). Cerebellar Purkinje cells (PCs) are predominantly affected in SCA2. The cause of PC degeneration in SCA2 is un...

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Autors principals: Liu, Jing, Tang, Tie-Shan, Tu, Huiping, Nelson, Omar, Herndon, Emily, Huynh, Duong P., Pulst, Stefan M., Bezprozvanny, Ilya
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749883/
https://ncbi.nlm.nih.gov/pubmed/19625506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0660-09.2009
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