Orthogonal analytical approaches to detect potential contaminants in heparin

Heparin is a widely used anticoagulant and antithrombotic agent. Recently, a contaminant, oversulfated chondroitin sulfate (OSCS), was discovered within heparin preparations. The presence of OSCS within heparin likely led to clinical manifestations, most prevalently, hypotension and abdominal pain l...

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Bibliografiske detaljer
Main Authors: Guerrini, Marco, Zhang, Zhenqing, Shriver, Zachary, Naggi, Annamaria, Masuko, Sayaka, Langer, Robert, Casu, Benito, Linhardt, Robert J., Torri, Giangiacomo, Sasisekharan, Ram
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749844/
https://ncbi.nlm.nih.gov/pubmed/19805108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906861106
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