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Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance
Histone acetyltransferases (HATs) play important roles in gene regulation and DNA repair by influencing the accessibility of chromatin to transcription factors and repair proteins. Here we show that deletion of Gcn5 leads to telomere dysfunction in mouse and human cells. Biochemical studies reveal t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749492/ https://ncbi.nlm.nih.gov/pubmed/19683498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.06.015 |
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