Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance

Histone acetyltransferases (HATs) play important roles in gene regulation and DNA repair by influencing the accessibility of chromatin to transcription factors and repair proteins. Here we show that deletion of Gcn5 leads to telomere dysfunction in mouse and human cells. Biochemical studies reveal t...

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Main Authors: Atanassov, Boyko S., Evrard, Yvonne A., Multani, Asha S., Zhang, Zhijing, Tora, László, Devys, Didier, Chang, Sandy, Dent, Sharon Y.R.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749492/
https://ncbi.nlm.nih.gov/pubmed/19683498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.06.015
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