Differential Processing of Amyloid-β Precursor Protein Directs Human Embryonic Stem Cell Proliferation and Differentiation into Neuronal Precursor Cells

The amyloid-β precursor protein (AβPP) is a ubiquitously expressed transmembrane protein whose cleavage product, the amyloid-β (Aβ) protein, is deposited in amyloid plaques in neurodegenerative conditions such as Alzheimer disease, Down syndrome, and head injury. We recently reported that this prote...

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Bibliographic Details
Main Authors: Porayette, Prashob, Gallego, Miguel J., Kaltcheva, Maria M., Bowen, Richard L., Vadakkadath Meethal, Sivan, Atwood, Craig S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Molecular Basis of Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749153/
https://ncbi.nlm.nih.gov/pubmed/19542221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026328
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