Amino Acid Position-specific Contributions to Amyloid β-Protein Oligomerization

Understanding the structural and assembly dynamics of the amyloid β-protein (Aβ) has direct relevance to the development of therapeutic agents for Alzheimer disease. To elucidate these dynamics, we combined scanning amino acid substitution with a method for quantitative determination of the Aβ oligo...

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Detalhes bibliográficos
Main Authors: Maji, Samir K., Ogorzalek Loo, Rachel R., Inayathullah, Mohammed, Spring, Sean M., Vollers, Sabrina S., Condron, Margaret M., Bitan, Gal, Loo, Joseph A., Teplow, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749133/
https://ncbi.nlm.nih.gov/pubmed/19567875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038133
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