Intersubunit Coupling in the Pore of BK Channels

The structural basis underlying the gating of large conductance Ca(2+)-activated K(+) (BK) channels remains elusive. We found that substitution of Leu-312 in the S6 transmembrane segment of mSlo1 BK channels with hydrophilic amino acids of smaller side-chain volume favored the open state. The sensit...

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Bibliografiske detaljer
Main Authors: Wu, Ying, Xiong, Yu, Wang, Sheng, Yi, Hong, Li, Hui, Pan, Na, Horrigan, Frank T., Wu, Yingliang, Ding, Jiuping
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Membrane Transport, Structure, Function, and Biogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749109/
https://ncbi.nlm.nih.gov/pubmed/19561088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.027789
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