Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials

BACKGROUND: Bisphosphonates might modulate the development of symptomatic bone metastases in men with prostate cancer. The Medical Research Council (MRC) PR05 and PR04 randomised controlled trials assessed the use of sodium clodronate, an oral, first-generation bisphosphonate. We report the final an...

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Main Authors: Dearnaley, David P, Mason, Malcolm D, Parmar, Mahesh KB, Sanders, Karen, Sydes, Matthew R
Formato: Artigo
Idioma:Inglês
Publicado: Lancet Pub. Group 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748902/
https://ncbi.nlm.nih.gov/pubmed/19674936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(09)70201-3
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