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Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
Mutations in PARK8, encoding LRRK2, are the most common known cause of Parkinson's disease. The LRRK2 Roc-COR tandem domain exhibits GTPase activity controlling LRRK2 kinase activity via an intramolecular process. We report the interaction of LRRK2 with the dishevelled family of phosphoproteins...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2009
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748899/ https://ncbi.nlm.nih.gov/pubmed/19625296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp337 |
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