The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic

We investigated the preclinical characteristics of the neuroprotective effect of the prostaglandin E2 type 1 receptor (EP1) antagonist SC51089 in models of focal cerebral ischemia produced by occlusion of the mouse middle cerebral artery (MCA). We found that systemic administration of SC51089 (5 to...

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Hauptverfasser: Abe, Takato, Kunz, Alexander, Shimamura, Munehisa, Zhou, Ping, Anrather, Josef, Iadecola, Costantino
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748840/
https://ncbi.nlm.nih.gov/pubmed/18648380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2008.88
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