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Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
Toll-like receptors (TLRs) play a pivotal role in innate immunity and inflammation. Here we showed that genetic deficiency of Peli1, an E3 ubiquitin ligase, attenuates induction of proinflammatory cytokines by ligands of TLR3 and TLR4 and renders mice resistant to septic shock. Peli1 was required fo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748822/ https://ncbi.nlm.nih.gov/pubmed/19734906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1777 |
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