Preferentially increased nitration of α-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson’s disease

α-Synuclein is a major component of Lewy bodies, proteinacious inclusions which are a major hallmark of Parkinson’s disease (PD). Lewy bodies contain high levels of nitrated tyrosine residues as determined by antibodies specific for 3-nitrotyrosine (3NT) and via mass spectrometry (MS). We have devel...

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Bibliographic Details
Main Authors: Danielson, Steven R., Held, Jason M., Schilling, Birgit, Oo, May, Gibson, Bradford W., Andersen, Julie K.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748813/
https://ncbi.nlm.nih.gov/pubmed/19697948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac901176t
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