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Carbon-Deuterium Bonds as Probes of Dihydrofolate Reductase

Much effort has been directed towards understanding the contributions of electrostatics and dynamics to protein function and especially to enzyme catalysis. Unfortunately, these studies have been limited by the absence of direct experimental probes. We have been developing the use of carbon-deuteriu...

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Autors principals: Thielges, Megan C., Case, David A., Romesberg, Floyd E.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748670/
https://ncbi.nlm.nih.gov/pubmed/18412341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0779607
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