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Towards the Catalytic Mechanism of a Cysteine Ligase (MshC) from Mycobacterium smegmatis: An Enzyme Involved in the Biosynthetic Pathway of Mycothiol

Mycobacterium tuberculosis and other members of the Actinomycetes family produce mycothiol (MSH or Acetylcysteine-Glucosamine-Inositol, AcCys-GlcN-Ins) to protect the organism against oxidative and antibiotic stress. The biosynthesis of MSH proceeds via a five-step process that involves four unique...

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Detalhes bibliográficos
Main Authors: Fan, Fan, Blanchard, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748416/
https://ncbi.nlm.nih.gov/pubmed/19505149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900457x
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