Genetic and Pharmacologic Alteration of Cathepsin Expression Influences Reovirus Pathogenesis

The cathepsin family of endosomal proteases is required for proteolytic processing of several viruses during entry into host cells. Mammalian reoviruses utilize cathepsins B (Ctsb), L (Ctsl), and S (Ctss) for disassembly of the virus outer capsid and activation of the membrane penetration machinery....

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Bibliographic Details
Main Authors: Johnson, Elizabeth M., Doyle, Joshua D., Wetzel, J. Denise, McClung, R. Paul, Katunuma, Nobuhiko, Chappell, James D., Washington, M. Kay, Dermody, Terence S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748054/
https://ncbi.nlm.nih.gov/pubmed/19640986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01095-09
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