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Oxidative Stress-Induced Afterdepolarizations and Calmodulin Kinase II Signaling
In the heart, oxidative stress caused by exogenous H(2)O(2) has been shown to induce early afterdepolarizations (EADs) and triggered activity by impairing Na current (I(Na)) inactivation. Since H(2)O(2) activates Ca(2+)/calmodulin kinase II (CaMKII), which also impairs I(Na) inactivation and promote...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747806/ https://ncbi.nlm.nih.gov/pubmed/19038865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.183475 |
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