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No topoisomerase I alteration in a neuroblastoma model with in vivo acquired resistance to irinotecan
CPT-11 (irinotecan) is a DNA-topoisomerase I inhibitor with preclinical activity against neuroblastoma (NB) xenografts. The aim was to establish in vivo an NB xenograft resistant to CPT-11 in order to study the resistance mechanisms acquired in a therapeutic setting. IGR-NB8 is an immature NB xenogr...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2004
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747712/ https://ncbi.nlm.nih.gov/pubmed/15292932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602079 |
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