In Vivo Elimination of Acentric Double Minutes Containing Amplified MYCN from Neuroblastoma Tumor Cells Through the Formation of Micronuclei

Neuroblastoma, the most common solid extracranial neoplasm in children, shows an appreciable variability in clinical evolution. Amplification of the MYCN oncogene in this tumor is detected in 25 to 30% of cases and is associated with poor clinical outcome. In this study, quantitative polymerase chai...

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Autores principales: Valent, Alexander, Bénard, Jean, Clausse, Bernard, Barrois, Michel, Valteau-Couanet, Dominique, Terrier-Lacombe, Marie-José, Spengler, Barbara, Bernheim, Alain
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2001
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Short Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891958/
https://ncbi.nlm.nih.gov/pubmed/11337354
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