Avoidance of Transient Cardiomyopathy in Cardiomyocyte-Targeted Tamoxifen-Induced MerCreMer Gene Deletion Models

Cardiac myocyte targeted MerCreMer transgenic mice expressing tamoxifen-inducible Cre driven by the α-myosin heavy chain promoter are increasingly used to control gene expression in the adult heart. Here we show tamoxifen-mediated MerCreMer nuclear translocation can induce severe transient dilated c...

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Main Authors: Koitabashi, Norimichi, Bedja, Djahida, Zaiman, Ari L., Pinto, Yigal M., Zhang, Manling, Gabrielson, Kathleen L., Takimoto, Eiki, Kass, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747596/
https://ncbi.nlm.nih.gov/pubmed/19520971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.198416
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