Reelin signaling antagonizes β-amyloid at the synapse

Abnormal processing of the amyloid precursor protein (APP) and β-amyloid (Aβ) plaque accumulation are defining features of Alzheimer disease (AD), a genetically complex neurodegenerative disease that is characterized by progressive synapse loss and neuronal cell death. Aβ induces synaptic dysfunctio...

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Detalles Bibliográficos
Autores principales: Durakoglugil, Murat S., Chen, Ying, White, Charles L., Kavalali, Ege T., Herz, Joachim
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747222/
https://ncbi.nlm.nih.gov/pubmed/19805234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908176106
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