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Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration
Plexin cell surface receptors bind to semaphorin ligands and transduce signals for regulating neuronal axon guidance. The intracellular region of plexins is essential for signaling and contains a R-Ras/M-Ras GTPase activating protein (GAP) domain that is divided into two segments by a Rho GTPase-bin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747167/ https://ncbi.nlm.nih.gov/pubmed/19717441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906923106 |
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