Early Growth Response-1 Suppresses Epidermal Growth Factor Receptor–Mediated Airway Hyperresponsiveness and Lung Remodeling in Mice

Transforming growth factor (TGF)-α and its receptor, the epidermal growth factor receptor, are induced after lung injury and are associated with remodeling in chronic pulmonary diseases, such as pulmonary fibrosis and asthma. Expression of TGF-α in the lungs of adult mice causes fibrosis, pleural th...

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Autors principals: Kramer, Elizabeth L., Mushaben, Elizabeth M., Pastura, Patricia A., Acciani, Thomas H., Deutsch, Gail H., Khurana Hershey, Gurjit K., Korfhagen, Thomas R., Hardie, William D., Whitsett, Jeffrey A., Le Cras, Timothy D.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746988/
https://ncbi.nlm.nih.gov/pubmed/19188657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0470OC
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