Force Sensing by Extension of the Src Family Kinase Substrate, p130Cas

Physical force is implicated in many cell functions. However, the molecular mechanisms of force sensing are poorly understood. Here, we show that mechanical extension of p130Cas (Cas) in vitro and in vivo causes phosphorylation by Src family kinases with no apparent change in Src kinase activity and...

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Main Authors: Sawada, Yasuhiro, Tamada, Masako, Dubin-Thaler, Benjamin J., Cherniavskaya, Oksana, Sakai, Ryuichi, Tanaka, Sakae, Sheetz, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746973/
https://ncbi.nlm.nih.gov/pubmed/17129785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.09.044
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