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A novel germline mutation of PTEN associated with brain tumours of multiple lineages
We have identified a novel germline mutation in the PTEN tumour suppressor gene. The mutation was identified in a patient with a glioma, and turned out to be a heterozygous germline mutation of PTEN (Arg234Gln), without loss of heterozygosity in tumour DNA. The biological consequences of this germli...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746590/ https://ncbi.nlm.nih.gov/pubmed/12085208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600206 |
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