A novel germline mutation of PTEN associated with brain tumours of multiple lineages

We have identified a novel germline mutation in the PTEN tumour suppressor gene. The mutation was identified in a patient with a glioma, and turned out to be a heterozygous germline mutation of PTEN (Arg234Gln), without loss of heterozygosity in tumour DNA. The biological consequences of this germli...

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Detalhes bibliográficos
Main Authors: Staal, F J T, van der Luijt, R B, Baert, M R M, van Drunen, J, van Bakel, H, Peters, E, de Valk, I, van Amstel, H K P, Taphoorn, M J B, Jansen, G H, van Veelen, C W M, Burgering, B, Staal, G E J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746590/
https://ncbi.nlm.nih.gov/pubmed/12085208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600206
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