12/15-Lipoxygenase Is Required for the Early Onset of High Fat Diet-Induced Adipose Tissue Inflammation and Insulin Resistance in Mice

BACKGROUND: Recent understanding that insulin resistance is an inflammatory condition necessitates searching for genes that regulate inflammation in insulin sensitive tissues. 12/15-lipoxygenase (12/15LO) regulates the expression of proinflammatory cytokines and chemokines and is implicated in the e...

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Autores principales: Sears, Dorothy D., Miles, Philip D., Chapman, Justin, Ofrecio, Jachelle M., Almazan, Felicidad, Thapar, Divya, Miller, Yury I.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746280/
https://ncbi.nlm.nih.gov/pubmed/19787041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007250
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