Pharmacokinetic Analysis of Irinotecan Plus Bevacizumab in Patients with Advanced Solid Tumors

PURPOSE: To evaluate the effect of bevacizumab on the pharmacokinetics (PK) of irinotecan and its active metabolite. Exploratory analyses of the impact of variability in uridine diphosphate glucuronosyltransferase 1A (UGT1A) genes on irinotecan metabolism and toxicity were conducted. METHODS: This w...

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Bibliografiske detaljer
Main Authors: Denlinger, Crystal S., Blanchard, Rebecca, Xu, Lu, Bernaards, Coen, Litwin, Samuel, Spittle, Cynthia, Berg, Daniel J., McLaughlin, Susan, Redlinger, Maryann, Dorr, Andrew, Hambleton, Julie, Holden, Scott, Kearns, Anne, Kenkare-Mitra, Sara, Lum, Bert, Meropol, Neal J., O'Dwyer, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746259/
https://ncbi.nlm.nih.gov/pubmed/19415281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1008-7
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