Pharmacokinetic Analysis of Irinotecan Plus Bevacizumab in Patients with Advanced Solid Tumors

PURPOSE: To evaluate the effect of bevacizumab on the pharmacokinetics (PK) of irinotecan and its active metabolite. Exploratory analyses of the impact of variability in uridine diphosphate glucuronosyltransferase 1A (UGT1A) genes on irinotecan metabolism and toxicity were conducted. METHODS: This w...

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Detalhes bibliográficos
Main Authors: Denlinger, Crystal S., Blanchard, Rebecca, Xu, Lu, Bernaards, Coen, Litwin, Samuel, Spittle, Cynthia, Berg, Daniel J., McLaughlin, Susan, Redlinger, Maryann, Dorr, Andrew, Hambleton, Julie, Holden, Scott, Kearns, Anne, Kenkare-Mitra, Sara, Lum, Bert, Meropol, Neal J., O'Dwyer, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746259/
https://ncbi.nlm.nih.gov/pubmed/19415281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1008-7
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