Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery

DNA vaccines are an attractive approach to eliciting antigen-specific immunity. Intracellular targeting of tumor antigens through its linkage to immunostimulatory molecules such as calreticulin (CRT) can improve antigen processing and presentation through the MHC Class I pathway and increase cytotox...

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Autores principales: Best, Simon R., Peng, Shiwen, Juang, Chi-Mou, Hung, Chien-Fu, Hannaman, Drew, Saunders, John R., Wu, T.-C., Pai, Sara I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745985/
https://ncbi.nlm.nih.gov/pubmed/19622402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.07.005
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