An integrated approach to the interpretation of Single Amino Acid Polymorphisms within the framework of CATH and Gene3D

BACKGROUND: The phenotypic effects of sequence variations in protein-coding regions come about primarily via their effects on the resulting structures, for example by disrupting active sites or affecting structural stability. In order better to understand the mechanisms behind known mutant phenotype...

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Detalhes bibliográficos
Main Authors: Izarzugaza, Jose MG, Baresic, Anja, McMillan, Lisa EM, Yeats, Corin, Clegg, Andrew B, Orengo, Christine A, Martin, Andrew CR, Valencia, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745587/
https://ncbi.nlm.nih.gov/pubmed/19758469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S8-S5
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