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Biochemical and Biophysical Analysis of Five Disease-Associated Human Adenylosuccinate Lyase Mutants

Adenylosuccinate lyase (ASL), a catalyst of key reactions in purine biosynthesis, is normally a homotetramer in which three subunits contribute to each of four active sites. Human ASL deficiency is an inherited metabolic disease associated with autism and mental retardation. We have characterized fi...

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Bibliografiske detaljer
Main Authors: De Zoysa Ariyananda, Lushanti, Lee, Peychii, Antonopoulos, Christina, Colman, Roberta F.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745324/
https://ncbi.nlm.nih.gov/pubmed/19405474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802321m
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