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Biochemical and Biophysical Analysis of Five Disease-Associated Human Adenylosuccinate Lyase Mutants
Adenylosuccinate lyase (ASL), a catalyst of key reactions in purine biosynthesis, is normally a homotetramer in which three subunits contribute to each of four active sites. Human ASL deficiency is an inherited metabolic disease associated with autism and mental retardation. We have characterized fi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745324/ https://ncbi.nlm.nih.gov/pubmed/19405474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802321m |
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