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hCLCA2 is a p53-inducible inhibitor of breast cancer cell proliferation

hCLCA2 is frequently downregulated in breast cancer and is a candidate tumor suppressor gene. We show here that the hCLCA2 gene is strongly induced by p53 in response to DNA damage. Adenoviral expression of p53 induces hCLCA2 in a variety of breast cell lines. Further, we find that p53 binds to cons...

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Detalhes bibliográficos
Main Authors: Walia, Vijay, Ding, Ming, Kumar, Sumit, Nie, Daotai, Premkumar, Louis, Elble, Randolph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745301/
https://ncbi.nlm.nih.gov/pubmed/19654313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4101
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