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Secreted hCLCA1 Is a Signaling Molecule That Activates Airway Macrophages

The CLCA gene family produces both secreted and membrane-associated proteins that modulate ion-channel function, drive mucus production and have a poorly understood pleiotropic effect on airway inflammation. The primary up-regulated human CLCA ortholog in airway inflammation is hCLCA1. Here we show...

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Autori principali: Ching, John C. H., Lobanova, Liubov, Loewen, Matthew E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861482/
https://ncbi.nlm.nih.gov/pubmed/24349445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083130
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