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Celastrol potentiates radiation therapy via impairment of DNA damage processing in human prostate cancer

PURPOSE: Celastrol is an active ingredient of traditional herbal medicine and has recently been identified as a potent natural proteasome inhibitor. In this study, we evaluated the radiosensitizing potential of Celastrol in the human prostate cancer PC-3 model. MATERIALS AND METHODS: Clonogenic assa...

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Autors principals: Dai, Yao, DeSano, Jeffrey T., Meng, Yang, Ji, Qing, Ljungman, Mats, Lawrence, Theodore S., Xu, Liang
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745184/
https://ncbi.nlm.nih.gov/pubmed/19545787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2009.03.057
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