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Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen
BACKGROUND: Pharmacological high-throughput screening (HTS) represents a powerful strategy for drug discovery in genetic diseases, particularly when the full spectrum of pathological dysfunctions remains unclear, such as in Friedreich ataxia (FRDA). FRDA, the most common recessive ataxia, results fr...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2744904/ https://ncbi.nlm.nih.gov/pubmed/19703283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2377-9-46 |
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