HuR’s role in gemcitabine efficacy in pancreatic cancer: HuR upregulates the expression of the gemcitabine metabolizing enzyme, deoxycytidine kinase

RNA-binding protein HuR binds U- or AU-rich sequences in the 3′-untranslated regions (UTRs) of target mRNAs, stabilizing them and/or modulating their translation. Given HuR’s links with cancer, we studied the consequences of modulating HuR levels in pancreatic cancer cells. HuR-overexpressing cancer...

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Hoofdauteurs: Costantino, Christina L., Witkiewicz, Agnieszka K., Y, Yuki Kuwano, Cozzitorto, Joseph A., Kennedy, Eugene P., Dasgupta, Abhijit, Keen, Judith C., Yeo, Charles J., Gorospe, Myriam, Brody, Jonathan R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744447/
https://ncbi.nlm.nih.gov/pubmed/19487279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0371
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