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CASPASES AND IAPS: A DANCE OF DEATH ENSURES CELL SURVIVAL
In this issue of Molecular Cell, Ditzel et al show that DIAP1 polyubiquitinates DRONC, DCP-1 and drICE, leading to their non-degradative inactivation. Surprisingly, activation of DIAP1 requires caspase-mediated cleavage, revealing an elegant feedback mechanism by which caspases regulate their own fa...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2744384/ https://ncbi.nlm.nih.gov/pubmed/19026777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.11.005 |
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